인간 게놈(genome, 유전체) 정보 1시간內 해독 가능할까?

Nat. Nanotechnol., 6, 162-165 (2011) | doi:10.1038/nnano.2010.283

 

Fast DNA sequencing with a graphene-based nanochannel device

Seung Kyu Min^‡, Woo Youn Kim^†‡, Yeonchoo Cho and Kwang S. Kim^*

 

Center for Superfunctional Materials, Department of Chemistry and Department of Physics, Pohang University of Science and Technology, Hyojadong, Namgu, Pohang 790-784, Korea; ^†Present address: Department of Chemistry, KAIST, Daejeon 305-701, Korea; ^‡These authors contributed equally to this work.

 

Devices in which a single strand of DNA is threaded through a nanopore could be used to efficiently sequence DNA^1-9. However, various issues will have to be resolved to make this approach practical, including controlling the DNA translocation rate, suppressing stochastic nucleobase motions, and resolving the signal overlap between different nucleobases^4,7. Here, we demonstrate theoretically the feasibility of DNA sequencing using a fluidic nanochannel functionalized with a graphene nanoribbon. This approach involves deciphering the changes that occur in the conductance of the nanoribbon^10,11 as a result of its interactions with the nucleobases via π–π stacking^12,13. We show that as a DNA strand passes through the nanochannel¹⁴, the distinct conductance characteristics of the nanoribbon^15-17 (calculated using a method based on density functional theory coupled to non-equilibrium Green function theory^18-20) allow the different nucleobases to be distinguished using a data-mining technique and a two-dimensional transient autocorrelation analysis. This fast and reliable DNA sequencing device should be experimentally feasible in the near future.

 

 

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*.  인간 게놈 해독 시간 추이(13년->4년->4개월->3개월->1일(아직 검증 결과 아님) ->1시간?

*. 그렇다면 맞춤의학 시대 즉, 개별 인간 유전체 해독 + 맞춤 질병 예방 및 치료정보 제공

    1인당 서비스료 1000불 이내로 하면 보편적인 서비스 즉, 상용화가 가능할 것 같은데

    이같은 일이 언제쯤 현실이 될까?

*.  개인적 의견으로 짜임새있게 연구를 진행하면 국내에서 5년내 상용화 가능할 듯...

     이를 차질없이 수행하기 위하여 나도 그 구심점의 일원이 되었으면 했는데 오늘은 정말 기쁜 날이다. 

     여기에 과제 사업 총괄 및 자문 역할까지 기대할 수 있어서.. 2012.12.21.